At the beginning of his course, an accomplished pathologist said, and we paraphrase:
All we are going to look at in this course is altered histology. If you have mastered
histology, you have mastered pathology. You see within a pathologic specimen rem-
nants of the tissue from which it came
Though it could be argued that this is an overly simplistic view, there is nevertheless a
great deal of truth in it.
Successful and productive careers in the healthcare professions are the result of an inter-
connected educational process. An understanding of basic science is greatly enhanced by
considering it within an appropriate clinical context, and, conversely, a successful diagnosis
requires an understanding of how disease has altered the structure and function of the nor-
mal body. Recognition of this interconnectedness has been an important consideration in the
development of this book.
A variety of issues have infl uenced the educational playing F eld in recent years. These
include (1) a changing population of basic biomedical instructors, (2) pressures for premedical
and medical education curriculum change, and (3) the compelling need to integrate basic
courses with clinical medicine. The latter point is especially important. Even as curricula are
being revised, there is a clear expectation that the clinical relevance of basic science information
should be emphasized. Clinical correlations, when appropriately integrated, result in a more
effective learning experience, which promotes the understanding of the relationships between
the normal and the abnormal as well as between the healthy state and the diseased state. Clini-
cal correlations also facilitate learning clinical concepts and enhance students’ understanding
of basic science information, especially as they relate to their speciF c career objectives.
The goal of
Atlas of Histology with Functional and Clinical Correlations
is not only to
provide a practical and useful source of fundamental information concerning basic histology
but also to do so using an innovative approach that shows how tissues can be modiF
ed by
a pathological process. This integrated approach emphasizes learning both normal structure
how the same tissues would appear in an abnormal state. We believe this approach will
provide a bridge for students between knowledge of basic histology and information that will
directly contribute to their future understanding of clinical concepts.
This “Atlas with Extras” functions much like a combination atlas and text. These
“extras” consist of many structure and function correlations, expanded and informative
F gure descriptions, text boxes offering additional relevant information, the extensive use
of clinical examples and their correlation with histological constructs, and relevant electron
micrographs integrated throughout. Taken collectively, these features form a fl exible educa-
tional tool that can be adapted to a wide variety of teaching and learning environments.
Atlas of Histology with Functional and Clinical Correlations
comprises 21 chapters in 3
units—beginning with “Basic Principles of Cell Structure and ±unction” and then progress-
ing to “Basic Tissues” and, F
nally, to “Organ Systems.” Using a proven-effective building-
block approach, this book starts with an introduction to the cell using light and electron
microscopic images—“visual deF
nitions” of the terms that will be used throughout the book.
The remaining chapters fl ow in a logical manner through increasingly more complex tissues
and organs, illustrating the essentials in color photos and drawings (normal and abnormal)
and in electron micrographs.
The three general concepts that have been followed in this book are to arrange related
information on facing pages; to emphasize the interrelation of structural, functional, and
clinical information; and to use meaningful clinical examples. More speciF
cally, the concepts
informing the creation of this atlas are as follows.
, the F
gure numbers are color coded: Those for histological sections and for TEM
and SEM are yellow, those for line drawings are highlighted in purple, and those for
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