CHAPTER 2
Cell Structure and Function
23
Figure 2-10A.
Steroid hormone–secreting cells, adrenal cortex.
EM,
3
21,000
Smooth
endoplasmic
reticulum
Nuclear
envelope
Nucleolus
Mitochondrion
with tubular
cristae
Rough
endoplasmic
reticulum
Lipid
droplet
Secondary
lysosome
Golgi
complex
A
Red cells in
Red cells in
capillary
capillary
Red cells in
capillary
Cytoplasm filled
Cytoplasm filled
with lipid droplets
with lipid droplets
Cytoplasm filled
with lipid droplets
Eosinophilic
Eosinophilic
cytoplasm
cytoplasm
Eosinophilic
cytoplasm
Nucleolus
Nucleolus
in nucleus
in nucleus
Nucleolus
in nucleus
B
Adrenal
cortical
cells
,
testicular
interstitial
cells
, and
ovarian
follicular
cells
are examples of cell types that function to
synthesize
and
secrete steroid hormones
. Each of these cells have in common the equipment needed for synthesis of steroid hormones. The neces-
sary components include
lipid droplets
containing cholesterol esters as substrates,
SER
, and
mitochondria
that function together in
the synthesis of hormones. The mitochondria characteristically have
cristae
that are
tubular
rather than shelfl
ike.
Figure 2-10B.
Light microscopic appearance
of steroid hormone–secreting cells.
H&E
,
3
800
main panel and inset
Light microscopic views of
steroid hormone–
synthesizing cells
reveal only a hint of the
distinctive set of structures that characterize
the cytoplasm of these cells. The
eosinophilia
(
acidophilia
) of the
cytoplasm
is largely attribut-
able to the abundance of mitochondria. Steroid
hormone–secreting cells vary in the amount of
cholesterol stored in the form of
lipid droplets
,
which appear in most preparations as empty
vacuoles because their contents are extracted
during specimen preparation. The cells in the
main
panel
are in the
zona
reticularis
and have
few droplets, similar to the cell in the electron
micrograph (Fig. 2-10A). The cells in the
inset
are from the
zona
fasciculata
and have numer-
ous lipid droplets.
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