312
UNIT 3
Organ Systems
Figure 16-6A.
Mucous acinus, submandibular gland.
EM,
3
6,818; inset (
color
) H&E,
3
598
This is an example of a
mucous acinus
, showing numerous large
secretory granules
in the apical region of the cells. These granules
contain
mucins
, which are synthesized within the cells. The nuclei of the mucous cells are fl
attened and lie against the basement
membrane. Mucous cells have less RER than serous cells.
Myoepithelial cells
share the basement membrane with mucous cells.
Myoepithelial cells have long
cellular processes
that can contract, promoting mucous cells to discharge their secretory products into
the lumen of the intercalated ducts.
Nucleolus
Nucleolus
Secretory
Secretory
granules
granules
Secretory
granules
Nucleus of mucous
Nucleus of mucous
acinar cell
acinar cell
Nucleus of mucous
acinar cell
Process of
Process of
myoepithelial cell
myoepithelial cell
Process of
myoepithelial cell
Lumen
Lumen
Lumen
Nucleus of the
Nucleus of the
myoepithelial cell
myoepithelial cell
Nucleus of the
myoepithelial cell
Mucous
acinar cell
Lumen
Lumen
Lumen
Nucleus of
mucous
acinar cell
A
Nucleolus
CLINICAL CORRELATION
Squamous cell
carcinoma
Submandibular
gland
B
Figure 16-6B.
Squamous Cell Carcinoma of the Tongue.
H&E,
3
83
Squamous cell carcinoma
of the tongue
is a
malignant oral
neoplasm
representing the most common intraoral cancer.
Squamous cell carcinoma is usually asymptomatic in the early
stages, but local pain, difF
culty swallowing, and
dysphagia
are common in the late stages. Clinically, the
neoplasm
may
appear as a red or white nonhealing ulcer or exophytic mass,
most commonly found on the lateral aspect of the tongue.
This image shows a squamous cell carcinoma on the fl
oor
of the mouth invading the submandibular glands. The major
risk factors for oral and tongue squamous cell carcinoma
include
smoking
and
alcohol consumption
,
chronic irrita-
tion
, and
chewing tobacco
. Pathologically, the cancer cells
show large, irregular and darkly stained nuclei. This cancer
tends to metastasize though the lymphatic system. Surgical
removal of the primary growth and related lymphatic nodes,
chemotherapy, and radiation therapy are treatment options.
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