An Illustrated Glossary of Histological and Pathological Terms
is a form of necrosis characterized by obliteration of the under-
lying tissue architecture and the formation of amorphous granular necrotic debris,
which grossly appears “cheesy,” hence the name
. Caseous necrosis is
highly characteristic of infection with
and certain fungi and is a
type of granulomatous inﬂ ammation.
This image shows a lymph node biopsy with granulomatous inﬂ ammation and
to the right of the dashed line
) in a patient with
is a form of necrosis characterized by preservation of cellular
outlines. Examples include necrosis of cardiac myocytes in myocardial infarction
This image shows global coagulative necrosis in a transplanted kidney due
to compromised perfusion after the transplant. Note the preserved architecture
with the glomerulus in the center surrounded by renal tubules. Note also the pale
eosinophilic staining with lack of nuclear staining.
is a speciF
c type of necrosis seen in
age to adipocytes causes release of lipids and cell death followed by aggregates
of foamy macrophages containing the released lipids. ±at necrosis is seen in
damage to fatty tissue by trauma as well as enzymatic digestion as seen in acute
This image shows fat necrosis in subcutaneous adipose tissue after pre-
vious surgery. Note the abundant foamy macrophages containing lipid droplets
may be seen after bacterial infections or infarcts involving the
central nervous system.
This image shows liquefactive necrosis in an infarcted area of the brain.
Note the intact white matter in the
of the image and the granular
liquefactive necrosis in the
of the image.
, is the result of a complex healing process involving an ini-
tial inﬂ ammatory response followed by the formation of new blood vessels, tissue
remodeling, and wound contraction. Abnormal healing processes include keloid
formation and hypertrophic scars.
This image shows a dermal scar characterized by horizontal collagenous
bands and an absence of skin adnexa–like hair follicles.
represents the death of living cells due to irreversible cell injury. Depending
on the tissue involved, necrosis will assume one of several morphologic patterns asso-
ciated with the processes involved in cell death.