Stem, Progenitor, and Precursor cells
are capable of differentiating into multiple cell lineages and can undergo proliferation indeF
are only capable of differentiating into a single cell lineage (restricted to one or two blood cell types) and
are morphologically undifferentiated.
can be recognized morphologically as undergoing differentiation along a particular blood cell lineage.
becomes progressively less basophilic because of dilution of ribosomes during the erythropoiesis process.
progressively decreases because of increased condensation of chromatin.
progressively decreases during the erythroid differentiation.
becomes progressively more eosinophilic because of increased accumulation of hemoglobin.
retains a round shape and no indentation occurs before it disappears.
decreases and nucleus becomes more condensed as in erythropoiesis.
changes from round or oval (promyeloblasts) to kidney shaped/slightly indented (myelocytes) and then
changes from deeply indented (metamyelocytes) to band shaped (band cells) and F
nally to lobed (mature granulocytes).
do not have speciF
c granules (only azurophilic granules); at this stage, it is too early to tell which granular
leukocytes they will become.
are the last developmental stage capable of dividing; speciF
c granules accumulate in this stage.
Pathological and Clinical Terms for Mature and Developing Blood Cells
Gray platelet syndrome
: This condition is characterized by a deF ciency or absence of the alpha granules and contents in
blood platelets, giving platelets a gray appearance in a Wright stain smear (±ig. 8-2B).
Platelet storage pool def
: Disorder caused by a decrease or absence of platelet delta granules (dense bodies),
which normally store and release adenine nucleotides and 5HT. “Platelet-type” bleeding is common with this deF
: Minute red or purple spots on the skin or mucous membranes caused by capillary hemorrhage; common causes
include physical trauma and decreased platelets (thrombocytopenia).
: Damaged lymphocytes seen on a peripheral blood smear caused by mechanical stress in the process of
producing the smear; although nonspeciF c, smudge cells are encountered more frequently on blood smears of patients with
chronic lymphocytic leukemia (±ig. 8-4C).
: Increased reticulocytes in the blood, often in response to blood loss, stimulation by erythropoietin treat-
ment, or treatment of iron deF ciency anemia with iron supplementation (±ig. 8-11C).
: Increased platelet count in the blood, which may be reactive or neoplastic, as in the disease essential
thrombocytosis (±ig. 8-12C).