152
UNIT 2
Basic Tissues
D. Cui
Neutrophilic
Neutrophilic
stab cell
stab cell
Eosinophilic
Eosinophilic
stab cell
stab cell
Basophilic
Basophilic
erythroblast
erythroblast
Neutrophilic
Neutrophilic
stab cell
stab cell
Eosinophilic
Eosinophilic
myelocyte
myelocyte
Eosinophilic
Eosinophilic
metamyelocyte
metamyelocyte
Neutrophilic
stab cell
Neutrophilic
stab cell
Eosinophilic
myelocyte
Eosinophilic
stab cell
Basophilic
erythroblast
Eosinophilic
metamyelocyte
Neutrophilic
Neutrophilic
myelocyte
myelocyte
Neutrophilic
myelocyte
Neutrophilic
Neutrophilic
stab cell
stab cell
Neutrophilic
stab cell
Neutrophilic stab cells
A
Figure 8-15A.
Stab (band) cells, bone marrow smear.
Wright
stain,
3
710; insets
3
1,569
Granular
metamyelocytes
mature to become
stab cells
, which
are also called
band cells
. The stab cells (mainly neutrophilic
stab cells) can be found in both the bone marrow and the
peripheral blood. Their nuclei are elongated and become band
and arch (or “C”) shaped, and the cytoplasm is the same as
that of mature neutrophils. These cells are the last stage of
granulocyte maturation without division, and in function and
structure, they are very close to mature neutrophils. The nuclei
of mature neutrophils become multilobulated (segmented),
contain dense
heterochromatin
, and often are described as
polymorphonuclear
(or
segmented
)
neutrophils
.
Proerythroblast
Proerythroblast
Proerythroblast
Neutrophil
Neutrophil
Neutrophil
Neutrophilic
Neutrophilic
stab cell
stab cell
Neutrophilic
stab cell
Neutrophilic
Neutrophilic
metamyelocyte
metamyelocyte
Neutrophilic
metamyelocyte
Polychromatophilic
Polychromatophilic
erythroblasts
erythroblasts
Polychromatophilic
erythroblasts
Orthochromatophilic
Orthochromatophilic
erythroblast
erythroblast
Orthochromatophilic
erythroblast
Eosinophil
Eosinophil
Eosinophil
B
Figure 8-15B.
Bone marrow cells, bone marrow smear.
Wright
stain,
3
710
This is an example of blood cells at various stages of develop-
ment in the
bone
marrow
, which includes both the
erythro-
cyte
and the
granulocyte series
. These cells, at various stages
of development, are densely packed together and can be found
randomly distributed in the bone marrow. During the matura-
tion process, the cell size becomes smaller and nuclei become
denser. In the
erythropoiesis series
, the cytoplasm of cells
becomes light blue and then more pink, and nuclei become
much denser and smaller and F nally disappear. In the
granu-
locytopoiesis series
, the cytoplasm becomes less blue, primary
(nonspeciF
c) granules are produced, and then speciF
c granules
are produced and are present in myelocytes, which gives these
cells the appearance characteristic of their identity as a neutro-
phil, eosinophil, or basophil. In other changes, nuclei become
progressively denser, and the shape changes from round to
oval, elongated, indented, and then lobed (segmented).
Reticular tissue
Reticular tissue
Reticular tissue
Adipocyte
Adipocyte
spaces
spaces
Adipocyte
spaces
Blood cells
Blood cells
Blood cells
C
Figure 8-15C.
Bone marrow, bone marrow smear.
Wright
stain,
3
35; inset
3
184
Bone marrow
is a specialized example of a
reticular connec-
tive tissue
, a loose connective tissue in which numerous cells are
supported by a delicate network of reticular F bers. It resides in
cavities within bones (see ±igs. 5-8, 5-10, and 5-11). Bone mar-
row can be categorized into
red bone marrow
and
yellow bone
marrow
. The term
red bone marrow
denotes active
hematopoi-
esis
;
yellow bone marrow
refers to a marrow composed chiefl
y
of
adipocytes
(
fat
cells
). Pictured is a smear of red bone marrow,
which contains many developing blood cells, a few
adipocytes
,
and some thin-walled blood vessels (sinusoidal capillaries). The
red bone marrow is organized into a
hemopoietic compartment
and a
vascular compartment
. The hemopoietic compartment is a
network of reticular F bers in which immature and mature blood
cells are suspended. The vascular compartment is composed of
mainly sinusoidal capillaries, which allow mature blood cells to
enter the blood circulation.
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